| 초록 |
Our research program has centered on the application of polymer-bound α-diazo-β-ketoesters as key building blocks for the diversity-oriented synthesis (DOS) of a series of heterocycle libraries, including oxazoles, indoles, imidazolones, pyrazinones and pyrazines. We recently discovered that o-nitroanilines served as excellent substrates in N-H insertion reactions with rhodium carbenoids derived from α-diazo-β-ketoesters. Furthermore, The resin-bound N-H insertion products were then cyclized readily in the presence of SnCl2 to yield the corresponding quinoxalines, which can be further derivatized by a diversity-building, Lewis acid mediated amidation reaction upon cleavage. |
