| 학회 |
한국화학공학회 |
| 학술대회 |
2016년 가을 (10/19 ~ 10/21, 대전컨벤션센터) |
| 권호 |
22권 2호, p.1455 |
| 발표분야 |
고분자 |
| 제목 |
Engineering of Thermoresponsive Polymeric Hydrogels for Fluorescent Color Switching by FRET Distance Modulation |
| 초록 |
A hydrogel has attracted significant interest in chemical and biomedical field due to the high degree of freedom for shapes, portability, and workability. In this study, we developed a hydrogel-based fluorescent thermometer using organic dyes labeled temperature-responsive copolymer system. N-isopropylacrylamide (NIPAAm) was chosen as a thermally-responsive spacer between green and red emitting dyes in order to make conformational change by temperature, while randomly polymerized acrylates were used to regulate water swelling ratio of the hydrogel. The spatial proximity of Förster resonance energy transfer (FRET) between donors and acceptors incorporated in the hydrogel can be tuned via thermo-induced collapsing and swelling of the platform at the lower critical solution temperature of NIPAAm, leading to the facile modulation of FRET efficiencies. In addition, our hydrogel system showed excellent signal-to-noise ratio and reversibility, indicating an ideal platform for biological and environmental applications. The detailed behavior of our system was investigated using photoluminescence and microscopy measurements. |
| 저자 |
배진우1, 박찬호1, 이준혁1, Kin Liao2, 김범준1
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| 소속 |
1한국과학기술원, 2Khalifa Univ. |
| 키워드 |
기능성고분자 |
| E-Mail |
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| 원문파일 |
초록 보기 |
