| 학회 |
한국고분자학회 |
| 학술대회 |
2002년 가을 (10/11 ~ 10/12, 군산대학교) |
| 권호 |
27권 2호, p.321 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Micelle-Forming and Thermosensitive Block Copolymers Composed of Poly (ε-caprolactone) and Poly (N-isopropylacrylamide) |
| 초록 |
Recently, there has been much interest in the synthesis and characteristics of amphiphilic block copolymers owing to the unique molecular architecture and different chemical nature. In this study, the well-defined poly (ε -caprolactone) (PCL)/poly (N-isopropylacrylamide) (PNIPAAm) diblock copolymers were synthesized through combining radical polymerization of NIPPAAm and the controlled coordination-insertion ring-opening polymerization of CL using an aluminum alkoxide macroinitiator formed from the equimolar reaction of triethylaluminum with hydroxy-terminated PNIPAAm (PNIPAAm-OH). Molecular characterization of PCL/PNIPAAm diblock copolymers was confirmed through 1H-NMR, FTIR and GPC analysis. Polymeric micelles composed of PCL as a hydrophobic core and PNIPAAm as a hydrophilic shell were prepared by a diafiltration method. The sizes and shapes of the thermosensitive micelles were investigated with a dynamic light scattering (DLS) spectrometer and with a transmission electron microscope (TEM). Also, NMR studies on LCST and core-shell structure of the micelles were performed. |
| 저자 |
정택웅1, 채지만*2, 장미경*3, 방은정, 조종수**, 나재운*
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| 소속 |
1한국기초과학지원(연), 2*순천대, 3**서울대 |
| 키워드 |
Poly (ε-caprolactone); Poly (N-isopropylacrylamide); thermosensitive; micelle
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| E-Mail |
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