| 학회 |
한국화학공학회 |
| 학술대회 |
2002년 가을 (10/24 ~ 10/26, 서울대학교) |
| 권호 |
8권 2호, p.4689 |
| 발표분야 |
고분자 |
| 제목 |
Protein Crystals on Lipids: Physical Chemistry in Nature |
| 초록 |
We are studying the macroscopic morphology and molecular arrangement of two-dimensional streptavidin crystals bound to biotinylated lipid monolayers at the air-water interface and in bilayer vesicles. We show how the symmetry breaking in the binding process alters crystal morphology and how changing the pH and ionic strength of the sub-phase can change the crystalline lattice structure. Then, using our understanding of the key interactions between neighboring proteins, we make point mutations to alter these interactions and change the crystal structure. Finally mixing wild-type and mutant proteins we can further tailor the crystal structure and morphology. Producing these crystals on the surface of vesicles provides analogies with protein coats on cell surfaces. We see the influence of an ordered layer of proteins on the mechanical properties of vesicles. |
| 저자 |
Alice P. Gast |
| 소속 |
MIT |
| 키워드 |
Protein Crystals; macroscopic morphology
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| E-Mail |
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| VOD |
VOD 보기 |
| 원문파일 |
초록 보기 |
