| 학회 |
한국고분자학회 |
| 학술대회 |
2004년 가을 (10/08 ~ 10/09, 경북대학교) |
| 권호 |
29권 2호, p.359 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Preparation and Application of Thermosensitive Nanoparticles Formed by Self-assembly of Poly(N-isopropylacrylamide)-Poly(ε-caprolactone) |
| 초록 |
Polymeric amphiphiles have been extensively studied in biotechnology and pharmaceutical fields due to their unique properties of micelle or micelle-like self-aggregate formation in aqueous milieu. In this study, the well-defined PNIPAAm-PCL was synthesized by ring-opening polymerization of ε-caprolactone using PNIPAAm-OH, prepared by telomerization of NIPAAm, as initiators. Thermosensitive nanaparticles formed by self-assembly of PNIPAAm-PCL in aqueous environment were prepared by a solvent evaporation method. The nanoparticles showed PCL block length dependent physicochemical properties such as lower critical solution temperature, particle size, and critical aggregation concentration. Then, the thermosinsitive nanoparticles were introduced into drug delivery systems with hydrophobic model drug of clonazepam, and their temperature sensitive release behaviors were investigated. |
| 저자 |
최창용1, 김태형1, 채수영1, 김동곤1, 장미경1, 정창남1, 조종수2, 나재운1
|
| 소속 |
1순천대, 2서울대 |
| 키워드 |
thermosensitive; nanoparticle
|
| E-Mail |
|
