| 초록 |
Among various hydrophilic and hydrophobic segments, hydrophilic polymers of PNIPAAm and PEG, and hydrophobic PCL have unique characteristics such as thermosensitiviey, biocompatibility, and biodegradation. In this study, the well-defined PNIPAAm-PCL and PEG-PCL block copolymers were synthesized by ring-opening polymerization of ε-caprolactone using mPEG-OH and PNIPAAm-OH, prepared by telomerization of NIPAAm, as initiators. Thermosensitive nanaparticles according to various ratios of PNIPAAm-PCL and PEG-PCL were prepared by a solvent evaporation method. The nanoparticles showed composition dependent physicochemical properties such as lower critical solution temperature, particle size, and critical aggregation concentration. Then, the thermosinsitive nanoparticles were introduced into drug delivery systems with hydrophobic model drug of clonazepam, and their temperature sensitive release behaviors were investigated. |
