| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 봄 (04/12 ~ 04/13, 제주 ICC) |
| 권호 |
32권 1호 |
| 발표분야 |
나노바이오기술용 고분자(의료용 고분자 부문위원회) |
| 제목 |
Thermosensitive Pluronic-Glycolide-META-Heparin binding TGF- β1 Hydrogel for proliferation and differentiation of Adipose-derived stem cells |
| 초록 |
Pluronics are nontoxic poly(ethylene oxide)-(polypropylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) triblock copolymers which form thermoreversible gels at high concentrations. Adipose-derived stem cells (ASC) are self-renewing stem cells that are easily isolated by differential sedimentation from processed liposuction material. ASCs can differentiate into various cell types including adipocytes, osteoblasts, chondrocytes, neurons, and multinucleated myocytes in response to lineage-specific induction factors. In this work, a functional Pluronic (F127) derivative, such as 4-Methacryloxyethyl trimellitic anhydride(META), glycolide and heparin-grafted Pluronic (F127-G5-META-Heparin) was synthesized and then the derivative was subjected to binding to transforming growth factor (TGF-β1). This Pluronic-based hydrogel system is expected to be useful as an injectable hydrogel for tissue regeneration. |
| 저자 |
정홍희1, 박귀덕1, 김병수2, 안광덕1, 한동근1
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| 소속 |
1한국과학기술(연), 2한양대 |
| 키워드 |
Pluronic F127; Heparin; TGF- β1; Adipose stem cell
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| E-Mail |
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