| 초록 |
Conductive hydrogels have been studied in order to improve the performance of conventional bionic devices, which use to replace or augment sensory neuron function. In this study, the conductive hydrogel extracellular matrix was designed to recapitulate cellular interactions and microenvironments in living tissue. The hydrogel extracellular matrix was fabricated to electrical conductivity by integrating with pyrrole-functionalized poly(amino acid)s. Then, the hydrogel patterned by the micro-contact printing (μCP) method could spatially organize PC12 neuronal cells and C2C12 skeletal myoblasts in the designated geometries. Finally, specific electrical stimulation triggered the hydrogel extracellular matrix to examine functional interactions and contractile forces in a neuromuscular junction. Overall, this new strategy to prepare the conductive hydrogel system using the functionalized poly(amino acid)s would be actively used for a broad array of Bio-MEMS. |
