| 학회 |
한국고분자학회 |
| 학술대회 |
2004년 봄 (04/09 ~ 04/10, 고려대학교) |
| 권호 |
29권 1호, p.69 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Transfection of Poly(4-vinylimidazole) in vitro and in vivo |
| 초록 |
Over the past decade there have been many attempts to design a nonviral vector to overcome the limitations of the viral vectors such as immunogenicity, oncogenicity, difficult production and purification, and target-cell specificities. In previous study, polymerization of 4-vinylimidazole(4V) prepared by decarboxylation of urocanic acid(UA) was carried out and used as a new gene carrier in vitro. It was found that the P4V formed a complex with DNA, and that the P4V/DNA complex exhibited very high transfection efficiency, through the proton sponge mechanism of the imidazole grows, and low cell toxicity. In this study, the transfection efficiency of the P4V/DNA complex was performed in vivo. |
| 저자 |
조종수1, 임종은1, 한기옥2, 한인권2, 한동근3, 안광덕3
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| 소속 |
1서울대, 2성균관대 의과대, 3한국과학기술(연) |
| 키워드 |
poly(4-vinylimidazole); gene carrier
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| E-Mail |
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