| 학회 | 한국고분자학회 |
| 학술대회 | 2004년 가을 (10/08 ~ 10/09, 경북대학교) |
| 권호 | 29권 2호, p.381 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Preparation of PVP-coated Iron Oxide Nanoparticle for MRI Contrast Agent |
| 초록 | Magnetic nanoparticles have been widely studied because of their potential application in biomaterial field such as magnetic resonance imaging. Among magnetic particles, iron oxide (Fe2O3, Fe3O4) has been extensively investigated1. However, magnetic nanoparticles tend to agglomerate as a result of their surface-to-volume ratio. One approach to solving this problem is to polymer coating. Common coating materials are dextran, starch, albumin, silicone and poly(ethylene glycol) (PEG). In this study, Poly(vinylpyrrolidone) (PVP) was used as coating materials. PVP is biocompatible, biodegradable and the most suitable polymeric modifier for prolonging the circulation lifetime in blood2. The synthesis consists of the thermal decomposition of organometallic precursor, Fe(CO)5, in the presence of PVP solution. (Figure 1) The two factors used in this experiment were polymer concentration and molecular weight. The TEM image showed PVP-coated iron oxide nanoparticles of ＜ 10 nm. (Figure 2) The size was controlled by polymer concentration and molecular weight. PVP-coated iron oxide nanoparticles were dispersed well in water. Acknowledgement : This work was supported by KMOCIE(10011394) Reference 1. L. Zhen, C. Hui, B. Haobo, and G. Mingyuan, Chem Mater, 16, 1391 (2004) 2. K. Yoshihisa, T. Yasuo, Y. Yasuo, K. Haruhiko, Y. Yoko, K. Hiroshi, T. Shin-ichi, O. Takayuki, M. Yohei, S. Hiroko, N. Shinsaku, and M. Tadanori, Biomaterials, 25, 3259 (2004) |
| 저자 | 이하영1, 임낙현1, 서진아2, 김문석3, 이해방3, 강길선1, 조선행3 |
| 소속 | 1전북대, 2한남대, 3한국화학(연) |
| 키워드 | iron oxide; nanoparticle; contrast agent |
