| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 봄 (04/08 ~ 04/10, 대전컨벤션센터) |
| 권호 |
40권 1호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Thermosensitive micelles block copolymers containing β-cyclodextrin for drug carrier application |
| 초록 |
A temperature-sensitive drug carrier system for prednisolone acetate (PA) based on β-cyclodextrin has been synthesized. Initially, block copolymers of poly(ethylene oxide)-b-poly(N-isopropylacrylamide-co-glycidyl methacrylate)) (PEO-b-PNIPAm-co-PGMA) were prepared by reversible addition-fragmentation chain transfer polymerization using a PEO macro-initiator. Subsequently, PEO-b-PNIPAm-co-PGMA copolymers were functionalized with β-cyclodextrin by epoxide ring-opening reaction, resulting in thermosensitive block copolymers with pendant cyclodextrin group which were then modified inclusion-complex formation of cyclodextrin with PA drug. The loading efficiency increased in the polymer β-cyclodextrin conjugate compared to native β-cyclodextrin. The thermo-responsive micelles enhanced cytotoxicity against human breast cancer cells in vitro. |
| 저자 |
김동우, Xuan Thang Cao, 이상호, 임권택
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| 소속 |
부경대 |
| 키워드 |
Thermo-responsive; poly(N-isopropylacrylamide); β-cyclodextrin; prednisolone acetate; inclusion-complex.
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| E-Mail |
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