| 초록 |
Chitosan, a natural nontoxic biopolymer, is produced by the deacetylation of chitin, which is a major component of the shells of crustaceans such as crab, shrimp, and crawfish. It has various bioactivities such as reduction of cholesterol, anticancer, immunity enhancement, wound-healing and antimicrobial effect. Thus, chitosan has received considerable attention for its commercial applications in the biomedical field, food, and chemical industries. But, chitosan is limited the application in various fields because of its poor solubility in water or organic solvent. To overcome this problem, we were developed low molecular weight water-soluble chitosan (LMWSC) for improved water solubility and bioactivity. In addition, we were prepared chitosan/herbal honey composite (AMCH) for reduction of atopic dermatitis (AD). And then, we evaluated the effects of AMCH on a mouse model of AD and found that it had a reducing activity in atopic phenomenon. |
