| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 가을 (10/06 ~ 10/07, 김대중 컨벤션센터) |
| 권호 |
36권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Release Behavior of Carvedilol by Manufacturing Method and Acidifier |
| 초록 |
In this study, we demonstrated the release behavior of carvedilol with the content of Kollidon K-30 (PVP K-30) and the effect of citric acid and fumaric acid as acidififiers on the release behavior of drug. The release behavior of the tablets was compared with Dilatrand® in the simulated gastric fluid (pH 1.2). Differential scanning calorimeter (DSC), X-ray diffraction (XRD), fourier-transform infrared spectroscopy (FT-IR) was measured for the physicochemical characterization of the tablets. In the case of carvedilol blended with Kollidon K-30 ratio of 1:5 was relatively higher than the others and the dissolution rate of tablets manufactured via lyophilization and rotary evaporator was higher than physical mixture. The dissolution rate of containing drug acidifiers were more pronounced. But, it was attributed by the rank of acidifiers leading to the decrease of dissolution rate. This research was supported by WCU (R31-20029). |
| 저자 |
조한수, 임동균, 오명준, 송정은, 심초록, 이동원, 강길선
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| 소속 |
전북대 |
| 키워드 |
Carvedilol; Kollidon K-30; Kollidon CL; Citric acid; Fumaric acid
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| E-Mail |
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