| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 가을 (10/13 ~ 10/14, 제주 ICC) |
| 권호 | 30권 2호 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | The Synthesis and Characterization of biodegradable PU/PEGDA IPNs |
| 초록 | In biomedical applications, biocompatibility, especially blood compatibility, is an important issue because biomaterials implanted in human body must perform without disturbing biological system1. When foreign material contacts with blood, thrombus is formed on the surface. Platelet adhesion is thought to induce a cascade reaction of coagulation factors, which results in thrombus formation2. We synthesized biodegradable hydrophobic polyurethane (PU) / hydrophilic poly (ethylene glycol) diacrylate (PEGDA) IPN having micro-separated structure to overcome the problems caused in the long-term clinical use. Hydrophobic polyurethane (PU) / hydrophilic poly (ethylene glycol) diacrylate (PEGDA) IPN was simultaneously synthesized with changing the molecular weight of PEGDA to investigate the effect of crosslinking density on the degree of phase separation. PU was modified using biodegradable poly (e- caprolactone) diol and the hydroxyl group of PEG was substituted to crosslinkable acrylate group having double bond, which induce photo-polymerization3. The structure of PEGDA was confirmed by NMR and the completeness of modified PU reaction was identified by the di-n-butylamine titration method4. All PU/PEGDA IPNs had micro-separated structure in which the PEGDA-rich phase formed the continuous matrix and the PU-rich phase formed the dispersed domain, since the reaction rate of PEGDA was faster than that of PU. The domain size of PU/PEGDA IPNs decreased as decreasing the molecular weight of PEGDA, which indicated an increase in the intermixing between the PU-rich phase and the PEGDA rich phase. All IPNs have sea-island morphology resulting from the suppressed phase separation. The effect of crosslinking density of PU and PEGDA and the effect of different composition of PU/PEGDA on morphology, surface hydrophilicity, thermal properties and mechanical properties was investigated5. Reference 1. B.D. Ratner, A.S. Hoffman, “Biomaterials Science; An introduction to materials in Medicine”, Academic Press, 1996 2. A.T. Nurden, P.Nurden, Balliere’s Clin.Haematol, 6, 653(1993) 3. S.S. Yoon, J.H. Kim, S.C. Kim, Polymer Bulletin, 53, 339-347(2005) 4. S.S. Kim, Y.M. Lee, C.S.Cho, Polymer, 36, 4497(1995) 5. Kataoka, K., et al., Macromol. Chem., Suppl., 9, 53(1985) |
| 저자 | 김화1, 윤 성수2, 김 성철1 |
| 소속 | 1한국과학기술원, 2LG Chem. |
| 키워드 | IPN |
