| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 가을 (10/06 ~ 10/08, 제주 ICC) |
| 권호 |
39권 2호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Fabrication of Aligned Nanofiber with Micropatterned Poly(ethylene glycol) Hydrogel for Myogenic Tissue Engineering |
| 초록 |
In this study, we fabricated 3D fibrous scaffolds to promote myogenic differentiation of mesenchymal stem cells (hMSCs). To create patterned structure, we used poly (ethylene glycol) (PEG) hydrogel and polycaprolactone (PCL) electrospun nanofiber. The resultant micropatterned 3D fibrous scaffold had parallel, vertical morphology of aligned fiber and hydrogel. This scaffold offered not only biomimetic structures but also suitable biochemical environment for cell differentiation by giving growth factor. The results showed that the aligned fibrous network and hydrogel alignment of 3D scaffolds were beneficial to induce myogenesis of hMSCs, and efficiency was higher than other systems without alignment of nanofiber or hydrogel. The fabricated multifunctional 3D fibrous scaffold indicates the potential for using practical tissue engineering. |
| 저자 |
국윤민, 한상원, 정의석, 김민수, 조강희, 민지홍, 고원건
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| 소속 |
연세대 |
| 키워드 |
aligned nanofiber; hydrogel; tissue engineering; hMSCs
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| E-Mail |
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