| 초록 |
Nanosize fiber architecture corresponding to native extracellular matrix (ECM) has given a great inspiration in the field of scaffold-based tissue engineering. While a variety of chemical or mechanical processes have been tried to mimic the nano-construct of ECM, electrospinning method has received a considerable interest thanks to the best morphological similarity to the nanofibril ECM. The electrospun nanofiber scaffold could be provided as an improved form of hybrid structure by combining with three-dimensional (3D) printing. As incorporating the 3D construction process, the nanofiber scaffold did not remain two-dimensional (2D) applications but could provide more enhanced features for practical use of scaffold. Additionally, by varying the nanofiber configurations into random and aligned morphology, the biomimetic functionalized scaffold could be achieved in terms of ECM-mimicking characteristics according to the native microscale anatomy of cartilage and muscle tissue. |
