| 초록 |
Nano-hydroxyapatite (N-HAp) has been used as a main component of bioactive nanocomposites for bone regeneration. Of many interesting properties, the cell-friendly features of N-HAp are ascribed to its unique surface properties. As another bioactive component, BMP-2 has been widely adopted to offer the scaffolds with enhanced osteoinductive property. BMP-2 plays a significant role for stem cell differentiation to osteoblasts, which cannot be accomplished by the use of n-HAp alone. In particular, the sustained release of BMP-2 at its free form is known to be effective in promoting new bone formation. Herein, we report on porous poly(L-lactide) (PLLA) scaffolds with surface-immobilized n-HAp that can release BMP-2 in a controlled manner. We demonstrate the synergistic effect of released BMP-2 with surface-immobilized n-HAp on in vivo osteogenic potentials. |
