| 학회 |
한국공업화학회 |
| 학술대회 |
2017년 가을 (11/08 ~ 11/10, 부산 벡스코(BEXCO)) |
| 권호 |
21권 2호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
The development of spinal implant incorporated with scaffold composed of collagen and thermoresponsive hydrogel chitosan as a drug delivery system for bone regeneration |
| 초록 |
In recent years, the use of orthopedic implants for spine impairments has been rapidly increased and become prevalent for lumbar interbody fusion. The PEEK has a much lower stiffness than other metal materials. When using it for spinal fusion cage, the stress in shielding bone graft and the slow-down fusion rate were observed for the PEEK clinical applications. We have developed to evaluate the osteocompatibility of the PEEK device filled with rhBMP-2 on sponge composed of collagen and thermosensitive hydrogel that was manipulated to release slowly of rhBMP-2. Osteogenesis induced by scaffold was evaluated by assay of ALP activity, PCR and immunoblotting to determine the degree of osteogenesis in vitro. Then, the in vivo effective bone regeneration was achieved with the rhBMP-2 loaded on scaffold higher bone mass and mineral density than that of the control showing the images of u-CT and H&E on the mouse calvarial critical size defect model and porcin disc implant model. |
| 저자 |
홍윤정1, 문지연1, 심혜은2, 이은경1, 박지혜2, 허강무3, 권보선2
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| 소속 |
1(주)위노바, 2(주)우리들휴브레인, 3충남대 |
| 키워드 |
spinal implant; scaffold; drug carrier; bone regeneration
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| E-Mail |
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