| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 봄 (04/10 ~ 04/11, 대전 컨벤션센터) |
| 권호 |
39권 1호 |
| 발표분야 |
휴먼인터페이스 의료용 고분자재료 (의료용 고분자 부문위원회) |
| 제목 |
M 13 Bacteriophage for Tissue Engineering |
| 초록 |
Precise control of the structural organization of regenerative tissue materials is critical for mimicking the natural tissue microenvironment. Genetically engineered phages have recently been shown to have great potential for use in developing novel tissue regenerative materials. A phage has several attributes that make them ideal for use in developing soft tissue engineering materials. Here, we report the use of a genetically engineered phage in optically readable phage-chip arrays for cell proliferation and morphology assays. We utilized previously developed M13 phages that were engineered to display integrinbinding peptide (RGD) or the biotin-like peptide (HPQ) for conjugating growth factors. We then prepared arrays of selfassembled phage matrices and characterized the growth of fibroblasts(NIH3T3) on these arrays using surface plasmon resonance (SPR) spectroscopy. We believed our chip can be used as novel and convenient toolkits for cell growth and morphology in tissue engineering. |
| 저자 |
오진우 |
| 소속 |
부산대 |
| 키워드 |
M13 bacteriophage; Cell proliferation; Tissue Engineering
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| E-Mail |
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