| 초록 |
Iron oxide nanoparticles with suitable biocompatible coatings have been widely used for magnetic resonance imaging. In the present study, Iron oxide nanoparticles were prepared by the thermal decomposition of iron(Ⅲ)acetylacetonate[Fe(acac)3], Oleic acid(OA) and oleylamine(OAm). Sulfo-SMCC were then coated onto the surface of the magnetite nanoparticles in order to introduce maleimide group on the surface. Finally, homing peptide AP-1, which obtained by phage display technique, was immobilized on the surface of the sulfo-SMCC coated for specific targeting. The magnetite nanoparticles were then characterized by X-ray diffractometer (XRD), fourier-transform infrared spectrophotometer (FT-IR), transmission electron microscopy (TEM), dynamic light scattering (DLS) and vibrating sample magnetometer (VSM). Interaction of homing peptide-conjugated nanoparticles with bladder cancer cells were investigated to examine intracellular uptake of the particles into target cells. |
