| 학회 |
한국공업화학회 |
| 학술대회 |
2019년 가을 (10/30 ~ 11/01, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
23권 2호 |
| 발표분야 |
포스터_생체재료 |
| 제목 |
C-phycocyanin-doxorubicin conjugate for synergistic chemo-photodynamic tumor therapy |
| 초록 |
C-Phycocyanin (CPC), a natural blue-colored pigment, is attracting attention due to its unique photodynamic activity, anti-inflammatory and anticancer properties. The aim of this study is to synthesize and evaluate a C-phycocyanin-doxorubicin (CPD) conjugate as a synergistic chemo-photodynamic tumor therapeutic agent. The CPD conjugate was successfully synthesized and formed self-assembled nanospheres in aqueous solution. After 635 nm laser irradiation, reactive oxygen species (ROS) in CT26 cells by CPC treatment was generated effectively. In addition, the production of ROS in CT26 cells by CPD treatment after the laser irradiation increased effectively enough to kill tumor cells. All these results indicate that CPD could become an attractive agent for chemo-photodynamic tumor therapy. |
| 저자 |
이호준1, 김민아1, 김예슬1, 박지선1, 김진2, 김동운3, 윤순도1, 이창문1
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| 소속 |
1전남대, 2조선대, 3광양보건대 |
| 키워드 |
C-Phycocyanin; Chemo-photodynamic therapy; Reactive oxygen species; Therapeutic agent
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| E-Mail |
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