| 초록 |
Repetitive polypeptides, defined as a protein consisting primarily of tandemly repeated blocks of amino acid sequence, are widely used biomaterials. These repetitive polypeptides can be used in the diverse biological fields including tissue engineering scaffolds, drug delivery systems, biomaterials, and DNA separation systems. Compared with the natural common proteins, repetitive polypeptides have a remarkable advantage in that their charges, molecular weights, and hydrophilic properties can be strictly controlled by changing the composition of the repeated amino acid sequence. This concept can be applied to the design of new polymeric biomaterials with improved properties, such as better defined biocompatibility, biorecognition, biodegradation, and stimuli sensitivity. Considering biomedical applications such as drug delivery and tissue engineering, these genetic engineered biomaterials are particularly attractive due to their ability to precisely place specific amino acids within a protein polymer. In this study, we introduced the genetic methods for the production of repetitive polypeptides as well as the biological applications of them. |
