| 학회 |
한국고분자학회 |
| 학술대회 |
2017년 가을 (10/11 ~ 10/13, 제주컨벤션센터) |
| 권호 |
42권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Bone Regeneration Using pDNA Complex-Loaded PCL/HA Microspheres in a Rat Model |
| 초록 |
Recently, tissue engineering technique combined with a gene delivery system has been considered as one of the promising therapeutic methods for tissue regeneration. In this study, pDNA (BMP-2 encoding) complex-loaded polycaprolactone (PCL)/hyaluronic acid (HA) microspheres were simply prepared by a spray/precipitation method using a double nozzle spray. The pDNA complex was efficiently loaded in the PCL/HA microspheres and continuously released from the microspheres for a long period of time. The bone regeneration behavior of the pDNA complex-loaded PCL/HA microspheres were investigated using a skull defect rat model. The pDNA complex-loaded PCL/HA microspheres showed faster bone regeneration than the control (blank) and PCL/HA microspheres without pDNA. |
| 저자 |
김태호1, 김호용2, 오세행2, 이진호1
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| 소속 |
1한남대, 2단국대 |
| 키워드 |
pDNA; Bone regeneration; Microspheres; Polycaprolactone; Hyaluronic acid
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| E-Mail |
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