| 학회 |
한국공업화학회 |
| 학술대회 |
2020년 가을 (10/28 ~ 10/30, 광주 김대중컨벤션센터(Kimdaejung Convention Center)) |
| 권호 |
24권 1호 |
| 발표분야 |
포스터-생체재료 |
| 제목 |
Nanoparticles as therapeutics based on the specific ion-releasing property for improving the angiogenic efficacy of adult stem cells |
| 초록 |
Here, we report that Fe ions can be delivered into human multipotent mesenchymal stem cells (hMSCs) using bioreducible metal nanoparticles (NPs) to enhance the angiogenic and cell homing efficacy of hMSCs by controlling ion-triggered intracellular reactive oxygen species (ROS) along with improved cell migration and reduced cytotoxicity. Treatment with the optimized amount of AuFe NPs led to a mild increment in intracellular ROS levels in hMSCs. As a result, Fe ions delivered to hMSCs additionally enhanced the expression of HIF-1α induced by mild ROS generation. Compared with hMSCs without treatment, hMSCs treated with AuFe NPs showed significantly enhanced expressions of angiogenesis and lesion-targeting related genes and proteins. Transplantation of AuFe NPs-treated hMSCs in mice led to significantly enhanced angiogenesis and tissue regeneration in a wound-closing mouse model compared with no treatment or conventional hMSC transplantation. |
| 저자 |
임광범1, 정의영2, 유태경2, 방석호1
|
| 소속 |
1성균관대, 2경희대 |
| 키워드 |
angiogenesis; wound healing
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| E-Mail |
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