| 학회 |
한국공업화학회 |
| 학술대회 |
2020년 가을 (10/28 ~ 10/30, 광주 김대중컨벤션센터(Kimdaejung Convention Center)) |
| 권호 |
24권 1호 |
| 발표분야 |
포스터-생체재료 |
| 제목 |
Photo-activatable anti-cancer drug delivered for cancer treatment that activates in tumor microenvironments |
| 초록 |
Many studies have been studied on photo-activatable drug carrier for cancer treatment. However, the light-stimulated drug delivery has insufficient therapeutically effect for cancer treatment and unexpected side effects. We designed photo-activatable drug carrier (PAC) stimulated in tumor microenvironment that was hypoxia and light irradiation. The PAC embraced an anti-cancer drug and structural disruption via reactive oxygen species (ROS) through respond of photosensitizer in polysaccharides. In cancer tissue which is hypoxia, ROS was generated by the electron enriched polysaccharide structure. The ROS produced by PAC facilitated drug release in tumor hypoxic condition through laser irradiation. A drug loaded PAC exhibited toxicity in cancer cell line in low level of oxygen condition. Animal model experiments were performed that demonstrated of tumor specific delivery of the PAC. Thus, this study suggests efficient approach for cancer treatment and hypoxic conditional diseases. |
| 저자 |
정하윤, 박우람, 배병찬, 나건
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| 소속 |
가톨릭대 |
| 키워드 |
Cancer treatment; PDT; Tumor hypoxia
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| E-Mail |
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