| 학회 |
한국공업화학회 |
| 학술대회 |
2018년 봄 (05/02 ~ 05/04, 대구 엑스코(EXCO)) |
| 권호 |
22권 1호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Nucleic Acid Drugs Delivery via Rolling Circle Transcription for Cancer Therapy |
| 초록 |
siRNA has been received a great attention as emerging gene therapeutics due to its superior capacity of specific gene silencing on post-transcription level. Despite its superb potential as gene therapeutics, the clinical application of siRNA is still limited. The long chain siRNA has been proposed as strategy to enhance its stability and to achieve efficient delivery. Here, We developed the periodically repeated siRNA through RCT process band its delivery system using glycol chitosan derivatives. The synthesized ENCs has stable formation and protect the siRNA therapeutics against polyanion and nucleases attack formation in blood circulation. |
| 저자 |
남향수, 이종범
|
| 소속 |
서울시립대 |
| 키워드 |
siRNA; cancer therapy; tGC; rolling circle transcription
|
| E-Mail |
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