| 초록 |
Emerging field of medical imaging, i.e. Molecular Imaging, allows not a traditional image of anatomical changes, but a biological characterization of disease state at molecular or cellular lever. With combining molecular imaging technology and drug delivery system, a novel design of drug screening or new approaches in drug development can be designed with animal models. For example, polymer nanoparticles bearing near-infrared fluorescent can be utilized in determining optimized therapeutic dosages or the frequencies of drug administration. Nanoparticles also can be utilized as molecular probes for visualization of therapeutic efficacy in small animals. Design of novel polymeric nanoparticles with high specificity in cellular or molecular responses, application of molecular imaging probes as well as delivery carriers for therapeutic agent will be presented in current study. |
