| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 봄 (04/08 ~ 04/09, 대전컨벤션센터) |
| 권호 |
35권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Heparin-based Self-assembled Nanoparticle for Photodynamic Therapy |
| 초록 |
Photodynamic therapy (PDT) has been proposed as a useful theragnostic tool for cancer treatment. They generate highly reactive oxygen species when exposed to light and become highly cytotoxic. In spite of this interesting property of the photosensitizers as a therapeutic agent, their hydrophobicity has been the main cause of skin photosensitivity, which is the major side effect after PDT. Therefore, in this study, we prepared heparin/poly(β-benzyl-L-aspartate) (HP) amphiphilic conjugates and encapsulated pheophorbide-a (Pheo), one of the second generation PDT agents, into a self-assembled nanoparticle system of HP conjugates. Highly hydrophobic Pheo was successfully incorporated into HP nanoparticles during dialysis, and the drug-loading content depended on the feed weight ratio of drug. In the in vitro cell studies, the Pheo-loaded HP nanoparticles showed good cellular uptake and marked photocytotoxicity after light treatment, causing significant damage to cancer cell. |
| 저자 |
이립1, 김소연1, 박진영2, 최용두2, 이용규3, 허강무1
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| 소속 |
1충남대, 2국립암센터 분자영상치료 연구과, 3충주대 |
| 키워드 |
heparin; nanoparticle; photodynamic therapy; pheophorbide a
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| E-Mail |
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