| 초록 |
Recent trends in designing regenerative materials are to develop bioactive matrices to harness the body’s innate healing ability by various stimuli. Among these, hyperoxia (over 21% pO2) is well known as a therapeutic factor for tissue regeneration. While various strategies to induce hyperoxia have been reported, developing advanced hyperoxia-inducible biomaterials for tissue regeneration is still challenging. Herein, we develop a catalase-immobilized syringe (defined as Oxyringe) as a hyperoxic O2-generating platform via catechol-inspired catalase modification. Utilizing Oxyringe, we fabricate hyperoxia-inducible hydrogels with minimized catalase incorporation, inducing transient hyperoxia in vivo. Interestingly, we notice that our hyperoxic matrix facilitates the wound healing process, such as boosted macrophage infiltration, facilitated neovascularization, and enhanced tissue maturation. In sum, our bioactive matrix has excellent potential for enhanced in situ tissue regeneration. |
