| 학회 |
한국고분자학회 |
| 학술대회 |
2006년 봄 (04/06 ~ 04/07, 일산킨텍스) |
| 권호 |
31권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Novel Synthesis of pH/ Temperature Sensitive Block copolymers via atom transfer radical Polymerization |
| 초록 |
pH senstive block copolymers were synthesized by ATRP of sulfamethazine methacrylate monomer and amphiphilic diblock copolymers synthesized by ring opening polymerization of D,L-lactide/ε-caprolactone(LA/CL) and their sol-gel phase transition was investigated. Sulfamethazine oligomer(OSM) was introduced as a pH responsive moiety while PCLA-PEG-PCLA was used as biodegradable as well as temperature sensitive amphiphilic triblock copolymer. The OSM-PCLA-PEG-PCLA-OSM block copolymers were synthesized using Br-PCLA-PEG-PCLA-Br as an ATRP macroinitiator. Molecular weights of OSM were controlled by adjusting the monomer/initiator ratio. The macroinitiator was synthesized by coupling of 2-bromoisobutyryl bromide with HO-PCLA-PEG-PCLA-OH in the presence of triethylamine catalyst in dichloromethane. The block copolymer solution shows sol-gel transition by a little pH change in the range of 7.2 - 8.0. GPC and 1H-NMR were used for the characterization of the polymers synthesized. |
| 저자 |
피봉수, kasala Dayananda, 김봉섭, 김지흥, 이두성
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| 소속 |
성균관대 |
| 키워드 |
pH & temperature sensitive block copolymer; sol-gel transition; ATRP
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| E-Mail |
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