| 학회 |
한국재료학회 |
| 학술대회 |
2019년 가을 (10/30 ~ 11/01, 삼척 쏠비치 호텔&리조트) |
| 권호 |
25권 2호 |
| 발표분야 |
B. 나노화학/바이오 재료 분과 |
| 제목 |
Electrospun Drug Delivery Vectors for Enhanced Nanoparticle Administration |
| 초록 |
Development of drug delivery vectors primarily focused on the retention of bioavailability of therapeutic materials to induce effective administration over time. The incorporation of different drugs using electrospinning increases drug encapsulation efficiency to the scaffold due to its high surface area to volume ratio compared to other drug vector systems. This study was conducted to effectively deliver insulin to the physiological system via an efficient and effective drug encapsulation method with matching suitable drug release behavior. Preparation of electrospun fibers was done with dissolving the appropriate amount of chitosan to different concentrations of acetic acid and lactic acid solvents. The optimization of different electrospinning parameters in generating a stable Taylor cone was established using the selected solvents. A chitosan – insulin (CI) nanoparticle can be used for effective protein administration. Chitosan is capable of opening interconnecting tight junctions of epithelial cells which would allow higher permeation efficiency. The novelty of nanoparticle technology in drug administration arise to the limited reports on the bioavailability and biocompatibility profiles of the material. The study is focused to generate a biocompatible nanoparticle material to effectively establish drug administrations without producing cytotoxic abnormalities within the surrounding cells. Furthermore, the use of electrospinning allows the efficient incorporation, handling, and release of nanoparticle drugs upon its desired method of transmission. |
| 저자 |
Cuenca John Patrick1, Celine Abueva2, Byong Taek-Lee3
|
| 소속 |
1Department of Regenerative Medicine, 2Soonchunhyang Univ., 3Korea |
| 키워드 |
Electrospinning; Nanoparticle; Chitosan; Insulin; Drug delivery
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| E-Mail |
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