| 초록 |
Carbonized poly(N-isopropylacrylamide) (PNIPAAm) can be used for biosensor and bioimaging after acid treatment through two pathways, partial (F-PNIPAAm) and full (FNP) acid treatment. The carbonized treatment time can control the lower critical solution temperature (LCST) of PNIPAAm which offers material as biosensor based on a fluorescent quenching system. The FNP-PNIPAAm also showed reversible capability based on fluorescent intensity, with a high fluorescent signal observed at room temperature (25 ºC) but quenching at physiological temperature (37 ºC), enabling the reversible fluorescent on-off platform. This material showed good biocompatibility and in vitro bio-imaging using MDAMB, A-549, and MDCK cells. These FNPs exhibited tunable luminescence properties, high aqueous stability, and low cytotoxicity, suggesting potential applications in bio-labeling, bio-imaging, and optoelectronics. This work was supported by Korea National University of Transportation in 2017 |
