| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 봄 (04/08 ~ 04/10, 대전컨벤션센터) |
| 권호 |
40권 1호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Redox-responsive core cross-linked micelles of poly(ethylene oxide)-b-poly(glycidyl methacrylate) for drug delivery |
| 초록 |
The synthesis of redox-responsive core cross-linked micelles was carried out using “click” chemistry. Poly(ethylene oxide)-b-poly(glycidyl methacrylate) (PEO-b-PGMA) was prepared by the reversible addition fragmentation chain transfer polymerization using PEO-based macroinitiator and subsequently functionalized with azido groups. The core cross-linked micelles of the azide-functionalized PEO-b-PGMA-N3 were controlled using a disulfide-containing cross-linking agent. The anticancer prednisolone acetate drug-loaded core cross-linked micelles exhibited excellent stability under physiological conditions, while they underwent rapid dissociation in dithiothreitol (DTT) reduction circumstance, resulting burst release of drug. These redox-responsive core cross-linked micelles enhanced cytotoxicity against human breast cancer cells in vitro. |
| 저자 |
김동우, Xuan Thang Cao, 이상호, 임권택
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| 소속 |
부경대 |
| 키워드 |
Redox-responsive; Core cross-linked; Prednisolone acetate; Dithiothreitol.
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| E-Mail |
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