| 학회 |
한국고분자학회 |
| 학술대회 |
2005년 가을 (10/13 ~ 10/14, 제주 ICC) |
| 권호 |
30권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Enhancement of circulation time in vivo by surface modification of liposomes with ODA-grafted-comb polymer |
| 초록 |
To enhance the stability of liposome in serum and prolong the circulation time in bloodstream, a number of liposomes with various functionalities have been developed. Thus, we prepared the octadecylacrylate-grafted-comb polymer (OGC) conjugated liposomes (OGC-liposomes). The comb polymer was synthesized by radical polymerization and composed of octadecylacrylate (ODA) backbone as a hydrophobic anchor and short poly(ethylene oxide) side chains as a hydrophilic chain. The stability of OGC-liposomes was evaluated by measuring the amount of adsorbed protein in serum using Bradford assay. Doxorubicin encapsulated OGC-liposomes was prepared by remote loading method and its circulation time in blood, biodistribution and antitumor activity were evaluated after intravenous injection in mice. The OGC-liposomes showed higher stability than other liposomal groups. The doxorubicin encapsulated OGC-liposomes showed more prolonged circulation time than those of conventional and PEG-coated liposomes. Additionally, antitumor activity of OGC-liposomes was enhanced, comparing with other liposomal formulation groups. |
| 저자 |
황태원1, 한희동1, 성하수1, 김중현2, 신병철1
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| 소속 |
1한국화학(연), 2연세대 |
| 키워드 |
comb polymer; liposomes; long circulation; biodistribution
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| E-Mail |
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