| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 가을 (10/08 ~ 10/09, 광주과학기술원 오룡관) |
| 권호 |
34권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Model oligopeptide drug delivery into osteroclast |
| 초록 |
The intracellular delivery of exogenous proteins into living cells with the help of membrane-permeable carriers has gained much attention in recent years. In this research, Nanoparticels functionalized with dendritic guanidine and amine groups at the surface were designed respectively for the delivery of osteoclast inhibiting peptides drug into cells. FACS and spectrofluorimetry analysis showed all nanoparticles were uptaken by cells. In addition, nanoparticles functionalized with dendrtic guanidine groups demonstrate better ability to cross the cell membranes. Time course of uptake results suggested that the fluorescence intensity of drugs increased with time. Nanoparticles functionalized with dendritic guanidine groups entered into cells more faster than those functionalized with dendritic amine groups or naked drug. All carriers exhibited no significant cytotoxicity against osteoclast. |
| 저자 |
Chi Bo, 문효정, 정병문
|
| 소속 |
이화여자대 |
| 키워드 |
intracellular; guanidine; osteoclast
|
| E-Mail |
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