| 초록 |
Hydrogel nanoparticles (nanogels) have attracted growing interest in diverse biomedical applications, including drug delivery, gene delivery, and molecular imaging. We have recently developed a series of Pluronic nanocapsules that were shell cross-linked with heparin, polyethylenimine (PEI), poly(ethylene glycol), or gold nanoparticles. These nanocapsules exhibited a dramatic volume transition over a broad temperature range by thermally triggered micellization of cross-linked or grafted Pluronic copolymer chains in the nanocapsule structure. We are applying Pluronic/PEI nanocapsules as efficient delivery vehicle for siRNA. The large and rapid volume expansion of these nanocapsules induced by a short cold shock treatment broke up the endosome compartment, enabled the siRNA cargo to release into the cytoplasm for specific silencing of a target mRNA. These novel nanomaterials would hold great potential for cancer cell targeted delivery of various therapeutic agents. |
