| 학회 |
한국화학공학회 |
| 학술대회 |
2015년 가을 (10/21 ~ 10/23, 일산 KINTEX) |
| 권호 |
21권 2호, p.2512 |
| 발표분야 |
WISET 2015 여대학(원)생 팀제 연구지원 사업 결과 발표 |
| 제목 |
Dual Stimuli Responsive Polymeric Nanocarrier Based on Carboxylmethyl Dextran for Cancer Therapy |
| 초록 |
Self-assembled polymeric nanoparticles, composed of carboxylmethyl dextran(CMD) and poly(caprolactone)(PCL) using click chemistry, are promising nanocarriers for anticancer drugs. We introduce pyridinethandiamine (PED) and 2-(2-pyridinyldithio)ethylamine (PDA) for improving controlled drug release. PED is convert positively charge in mildly acidic condition. As a results, endocytosis of nanocarrier enhance on tumor microenvironment. That means more efficient drug delivery into tumor tissue. Also, nanocarrier can efficiently encapsulate hydrophobic drugs in physiological condition because PDA is formed crosslinked core using disulfide bond. But, when these are come into tumor site, structure of nanocarrier destroys by glutathione and drugs are more release than normal condition. In this study, we prepared bioreducible polymeric nanocarrier which can response against dual stimuli for cancer therapy. The physicochemical characteristics of the polymeric nanocarrier were investigated using 1H-NMR, DLS, UV/VIS spectrophotometer. |
| 저자 |
박재형1, 오현주2, 이명현2, 서민지3, 강지은3, 정유립1, 유혜연1, 전주은1
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| 소속 |
1성균관대, 2용화여자고등학교, 3서울영신고등학교 |
| 키워드 |
polycaprolactone; carboxylmethyl dextrane; polymeric nanocarrier; charge convertable; core crosslinking
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| E-Mail |
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| VOD |
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| 원문파일 |
초록 보기 |
