| 초록 |
Gene therapy to treat the genetic disease like cancer, restenosis has lot of importance in the field of biomedical science. Cationic polymers have been employed to aid in the delivery of genes. We employed the cationic polymer with modifications to deliver the genes. Modifications include polyethylene glycol attachment, introduction of disulfide bond and sorbitol group to the cationic polymer along with the degradable esters. Once these modifications were done the gene delivery was efficient without compromising the bio-compatibility. Imaging the delivery of the gene will help in visualizing the target place accumulation and distribution, so we have loaded the imaging agents like quantum dots, superparamagnetic ironoxides, indocyanin green etc to the modified polymeric carriers. Replacement of the missing genes or suppression of the overexpressed gene can be done through plasmid DNA, siRNA and microRNA delivery. |
