| 학회 |
한국고분자학회 |
| 학술대회 |
2020년 가을 (10/05 ~ 10/08, 부산컨벤션센터(BEXCO)) |
| 권호 |
45권 1호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Preparation of non-porous alginate-based hydrogel crosslinked via Diels-Alder Click chemistry for drug release application |
| 초록 |
Alginate-based hydrogels were prepared by Diels-Alder click reaction beween alginate-furfuryl amine (Alg-FA) and disulfide-maleimide crosslinkers (S-Ma). Results showed alginate-based hydrogels having a non-porous morphology, which produced no by-products since gelation was processed via addition reaction between FA and Ma groups. From the drug release test of the hydroges, the fast release continued during the first hour after the initial release test, followed by an extremely slow release till the 10thday. The initial rapid release could be attributed to the dense structure. Moreover, size increment after 10 days indicated the steric hindrance that prevented water molecules from diffusing freely. |
| 저자 |
이시윤, Sonita Afrita Purba Siboro, 조성우, 임권택
|
| 소속 |
부경대 |
| 키워드 |
alginate; hydrogels; disulfide crosslinkers; drug release; porosity
|
| E-Mail |
|
