| 학회 |
한국고분자학회 |
| 학술대회 |
2020년 가을 (10/05 ~ 10/08, 부산컨벤션센터(BEXCO)) |
| 권호 |
45권 1호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Surface-functionalized micro-fluidic chip for monitoring of drug efficacy toward mammalian cells |
| 초록 |
Micro-fluidic systems can be used in controlled drug release study for monitoring drug concentration in micro-level. Here, we fabricated a micro-fluidic device for the study of an anticancer drug efficiency and cell toxicity. For the study, drug-encapsulated hydrogel beads were synthesized and placed within a micro-channel of the device. We utilized layer-by-layer (LbL) deposition method to modify the surface of the micro-channels in the device in order to prevent bio-fouling as well as provide the better cell culturing condition. Since the cancerous cells were concentrated in the specific areas without contamination, this system performed as the optimal environment for the clear monitoring of pure drug efficiency. We also evaluated the drug efficacy toward cancer cells over normal cells. The results of this study indicate that the micro-fluidic device suitably surface-functionalized has high potential as the in-situ drug monitoring system. |
| 저자 |
이수진, 양성윤
|
| 소속 |
충남대 |
| 키워드 |
microfluidic chip; cell culture; drug release system; hydrogel particle
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| E-Mail |
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