| 초록 |
Cationic solid lipid nanoparticles (CSLN), bio-inspired and reconstituted from natural protein-free low density lipoprotein, were used for targeted delivery of siRNA therapeutics to the liver. The siRNA/CSLN complex exhibited an excellent in vitro gene silencing efficiency with an extremely low cytotoxicity. After intravenous injection, CSLN/siCTGF complexes were target specifically delivered to the liver in N-nitrosodimethylamine induced hepatic fibrosis animal models. The serial administrations of CSLN/siCTGF complexes resulted not only in a significant down regulation of CTGF, TNF and TGF-β1 but also a dramatic improvement of blood chemistry in liver fibrosis animal models. Taken together, CSLN were thought to be effectively exploited as a targeted delivery carrier of siRNA therapeutics to the liver for the treatment of hepatic fibrosis and cirrhosis. |
