| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 봄 (04/11 ~ 04/12, 대전컨벤션센터) |
| 권호 |
38권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Nucleic acid nanoparticles for the delivery of peptide-siRNA conjugates |
| 초록 |
Herein we demonstrate the structure and function relation of nucleic acid nanoparticles for siRNA delivery. Holiday junction and tetrahedron nanostructures are efficiently prepared by the programmable self-assembly of DNA strands. Cell penetrating peptide (CPP) conjugated siRNA can be site-specifically hybridized on either holiday or tetrahedron nanostructure to form CPP-siRNA/DNA nanoparticles. These nucleic acid nanoparticles are evaluated for the GFP gene silencing and they exhibit remarkable differences in gene silencing efficiency. This study clearly provides strong evidences for the importance of nanostructure design on the intracellular delivery of RNA therapeutics. |
| 저자 |
정은혜, 이혁진
|
| 소속 |
이화여자대 |
| 키워드 |
nanoparticle; siRNA
|
| E-Mail |
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