| 초록 |
Tandem intramolecular conjugate addition is conducted with α,β-bisenones as selected Michael acceptors which are converted into 1,2,3-trisubstituted 6-membered ring with activated sulfur nucleophiles in good to excellent yield up to 99% yield. Various substituted α,β-bisenones and sulfur nucleophiles are examined to expand the scope of this chemistry. Only one diastereomer is isolated from all following reaction because lithium iodide-mediated enolate trapping protocol improves stereoselectivity of 1,2,3-trisubstituted cyclohexanes. |
