| 초록 |
Marine mussel, can adhere to almost all types of surfaces even if under the wet condition, uses mussel foot protein for attach on the surface. Mussel foot protein is mainly composed of L-3, 4-dihydroxyphenylalanine (DOPA) and lysine. We developed a catechol-conjugated chitosan (Chi-C) for mimicking the chemical structure of the adhesive proteins. Chi-C can be a hydrogel form spontaneously. However, Chi-C has low modulus to maintain its structure in early stage. In this work, we demonstrated vanadium ion added Chi-C to apply bioink for 3D-printing system. In case of Chi-C, it takes over 3 hours to become solid-like state. Whereas, Vanadium added Chi-C (V-Chi-C) takes under 0.5 hour. Moreover, Chi-C shows poor shape fidelity due to low modulus. The trace amount of vanadium supports gelation of Chi-C. In conclusion, the enhanced modulus of the V-Chi-C provided good shape fidelity. Small amount vanadium could be allow for faster gelation of Chi-C. |
