| 초록 |
Biomaterials can be applied to engineer stem cell therapy for improved therapeutic efficacy and safety. In this talk, our recent effort using bio-inspired materials will be introduced to potentiate stem cell therapy by regulating self-renewal, proliferation, and differentiation of stem cells. Firstly, mussel-inspired surface modification was applied to prepare functional scaffolds and substrates for promoting neuronal and osteogenic differentiation of stem cells. Secondly, bio-inspired superhydrophobic substrates were developed as effective culture platforms to produce highly viable, functional stem cell spheroids with enhanced angiogenic potential. Finally, nanotopographical features mimicking aligned extracellular matrix were tested to enhance neurogenesis and osteogenesis of stem cells. These approaches for stem cell engineering combined with bio-inspired materials can potentiate stem cell therapy for the treatment of neurodegenerative diseases and orthopedic injuries. |
