| 학회 |
한국고분자학회 |
| 학술대회 |
2017년 가을 (10/11 ~ 10/13, 제주컨벤션센터) |
| 권호 |
42권 2호 |
| 발표분야 |
분자전자 부문위원회 I |
| 제목 |
Phosphorescence-Ratiometric Probe of Histamine |
| 초록 |
Detecting biological histamine emerges as an important task, because histamine is involved in a variety of pathophysiological processes. However, conventional methods for detection of histamine rely on multistep protocols, so their utility is limited by inability for real-time monitoring. We discovered ratiometric phosphorescence behaviors of a cyclometalated solvento complex of Pt(II) (PtGR) toward histamine. PtGR displayed red phosphorescence, but the addition of histamine resulted in a hypsochromic shift due to ligand exchange. Kinetic study revealed a bimolecular rate constant to be as large as 6.9 102 M1 s1. Phosphorescence titration also revealed a tight interaction between PtGR and histamine with a small dissociation constant. PtGR showed excellent selectivity to histamine over other nucleophilic biomolecules. Finally, we successfully demonstrated a correlation between the histamine concentrations determined by employing ELISA and phosphorescence ratio by PtGR. |
| 저자 |
박규림1, 유영민1, 김진주1, 김신희1, 유승연1, 류재찬2, 정연욱2, 류지환2
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| 소속 |
1이화여자대, 2연세대 |
| 키워드 |
phosphorescence; sensor; histamine; Pt complex
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| E-Mail |
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