| 초록 |
We suggest thermoresponsive nanovesicles for inducing drug release behavior by photothermal effect using near infrared (NIR) laser. The nanovesicle is composed of phospholipids and poly-(N-isopropylacrylamide-co-acrylamide) (PNIPAM). Melanin as a photo-heat conversion material was added. Nanovesicles had the mean diameter 177±14 nm. After NIR 808 nm laser irradiation at 1.5 W/cm2 for 7 min, the temperature of nanovesicle solution has increased from 20.5℃ to 51℃ and observed excellent photothermal effect of melanin. In drug release study, after the laser irradiation, 5-fluorouracil loaded into the nanovesicles showed the faster drug release behavior than the group not irradiated with the laser. Furthermore, as the amount of PNIPAM increased, the rate of drug release increased more rapidly. Consequently, the nanovesicles are useful as a drug delivery carrier for inducing and drug release behavior by NIR laser irradiation. |
