| 초록 |
Exosomes, cell-derived vesicles, can offer active yet specific cellular attraction to drug delivery applications. In this study, we propose an exosome-analogous drug delivery system which is established by using lipid/polymer hybrid vesicles with fusogenic peptide conjugates. The lipid/polymer hybrid vesicles are fabricated by co-assembly of phosphatidylcholine and poly(ethylene oxide)-b-poly(ɛ-caprolactone)-b-poly(ethylene oxide). Thanks to large size and slow dynamics of amphiphilic triblock copolymers at the bilayer membrane, the hybrid vesicles show long-circulating time and high drug loading efficiency. To evaluate the cell affinity of fusogenic exosomes, the interaction force between an exosome and a cell is characterized via microscale thermophoresis. Finally, in vitro cell-penetration study demonstrates the practical applicability of our artificial exosome as a remarkable cell delivery nanocarrier. |
