| 학회 |
한국공업화학회 |
| 학술대회 |
2018년 봄 (05/02 ~ 05/04, 대구 엑스코(EXCO)) |
| 권호 |
22권 1호 |
| 발표분야 |
콜로이드계면화학_포스터 |
| 제목 |
Dermal-epidermal junction-targeted transdermal delivery using phase modulus-tuned, cell penetrating peptide-tagged polymeric nanocarriers |
| 초록 |
We establish a new transdermal delivery system in which drug molecules encapsulated in polymeric micelles are delivered to dermal-epidermal junction (DEJ). For this, phase modulus-regulated polymeric micelles were fabricated via co-assembly of hybrid amphiphilic triblock copolymers, poly (ethylene oxide)-b-poly (ε-caprolactone)-b-poly (ethylene oxide) and poly (ethylene oxide)-b-poly (propylene oxide)-b-poly (ethylene oxide). The modulus of micelle phase could be controlled depending on the composition of triblock copolymers. To improve transdermal delivery, in vitro cell-penetration study was carried out using the polymeric nanocarriers conjugated with cell-penetrating peptide. Furthermore, we showed that the hybrid polymeric nanocarriers with well-tuned phase modulus as well as specific binding ability diffused readily into the stratum corneum and reached richly to the area of DEJ. |
| 저자 |
홍성준, 김진웅
|
| 소속 |
한양대 |
| 키워드 |
triblock copolymer; hybrid micelles; cell-penetration; transdermal delivery
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| E-Mail |
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