| 학회 |
한국화학공학회 |
| 학술대회 |
2009년 가을 (10/22 ~ 10/23, 일산 KINTEX) |
| 권호 |
15권 2호, p.1214 |
| 발표분야 |
고분자 |
| 제목 |
Synthesis of Biotin-Conjugated pH-Sensitive Polymeric Micelle for Tumor Targeting |
| 초록 |
The ligand-mediated nanoparticle is able to penetrate into target tumors easily because it has high binding affinity to a specific receptor on the surfaces of tumor cells. Biotin containing poly(ethylene glycol) grafted poly(β-amino ester) (Biotin-PEB), pH-sensitive amphiphilic block copolymer, was synthesized. The structure of Biotin-conjugated copolymers was confirmed by 1H NMR spectroscopy and the existence of biotin at the surface of the Biotin-PEB micelles was evaluated by HABA/Avidin binding assay. The size of the Biotin-PEB micelles was determined by dynamic light scattering measurement and the result showed that the polymeric micelle disrupted below pH 6.6. |
| 저자 |
김지현, 이두성
|
| 소속 |
성균관대 |
| 키워드 |
pH-Sensitive; Polymeric Micelle; Biotin Conjugate; Block Copolymer
|
| E-Mail |
|
| 원문파일 |
초록 보기 |
